儿童邻苯二甲酸酯类物质暴露的健康风险评估Health risk assessment of exposure to phthalates among children
于钏钏;王强;
摘要(Abstract)：
目的 检测儿童尿中邻苯二甲酸酯类物质(PAEs)代谢产物的浓度，评估儿童PAEs暴露的健康风险。方法 采用高效液相串联-质谱法检测202名一年级学生尿中8种PAEs代谢产物：邻苯二甲酸单(2-乙基己)酯(MEHP)、邻苯二甲酸单(2-乙基-5-羟己基)酯(MEHHP)、邻苯二甲酸单(2-乙基-5-氧己基)酯(MEOHP)、邻苯二甲酸单丁酯(MBP)和邻苯二甲酸单乙酯(MEP)、邻苯二甲酸单甲酯(MMP)、邻苯二甲酸单苄基酯(MBzP)和邻苯二甲酸单辛酯(MOP)的浓度；然后根据已知的生物监测当量(BE)和上述代谢产物浓度评估PAEs暴露的健康风险。结果 MEHP、MEOHP、MEHHP和MBP检出率均高于90%;经BE分析，所有学生发育毒性暴露风险系数<1.0,46%学生尿中邻苯二甲酸二丁酯(dibutyl phthalate, DBP)代谢物生殖毒性暴露风险系数>1.0,10%的女生尿中邻苯二甲酸二(2-乙基己基)酯(di-2-ethylhexyl phthalate, DEHP)代谢物肝毒性暴露风险系数>1.0。结论 该校一年级学生PAEs暴露存在潜在生殖损伤和肝损伤风险。
关键词(KeyWords)： 邻苯二甲酸酯;尿;暴露风险评估;生物监测当量;儿童
基金项目(Foundation): 中国疾病预防控制中心应急项目《室内环境对居民内分泌影响的研究》;; 国家卫生健康委与联合国儿童基金会环境与健康发展项目
作者(Authors): 于钏钏;王强;
DOI: 10.13421/j.cnki.hjwsxzz.2022.03.011
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