余日安

• 1:同济医科大学环境卫生学教研室!湖北武汉430030

摘要(Abstract)：

本文从 DNA损伤、癌基因 c- myc、c- fos、c- jun的表达、细胞凋亡的诱导等方面对镉的分子毒理学作用进行了概述。镉可以引起 DNA单链断裂 ,形成 DNA碱基修饰产物 8-羟基脱氧鸟苷 ,并损害 DNA修复系统。镉可以使癌基因 c- myc、c- fos、c- jun表达增强 ,其作用机制与镉破坏细胞内钙稳态、激活蛋白激酶 C等有关。镉通过使癌基因表达增强、增加细胞内钙水平以及造成氧化应激等 ,可诱导多种细胞凋亡。

关键词(KeyWords)： 镉;DNA损伤;癌基因;凋亡

Abstract:

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基金项目(Foundation):

作者(Author): 余日安

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