赵文莉;张立实;李宁;

• 1:四川大学华西公共卫生学院
• 2:四川大学华西公共卫生学院
• 3:中国疾病预防控制中心营养与食品安全所 四川成都100062
• 4:四川成都100062

摘要(Abstract)：

人参是我国传统的滋补养生名贵药材,人参皂甙是人参的主要功效成分。目前国内外体内、体外实验以及流行病学调查研究表明,人参皂甙对中枢神经系统、心血管系统、血液与造血系统、内分泌系统、免疫系统、肝脏和肾脏等器官都具有重要的药理作用,此外人参皂甙的安全性也引起学者的广泛关注。本文就人参皂甙的药理作用及其毒性作用的研究进展进行综述。

关键词(KeyWords)： 人参皂甙;药理研究;毒性作用

Abstract:

Keywords:

基金项目(Foundation): 国家科技部“十一五”支撑项目(2006NAK02A07)

作者(Authors): 赵文莉;张立实;李宁;

参考文献(References)：

• [1]　LI X,WANG G,SUN J,et al.Pharmacokinetic and absolute bioavailabilithstudy of total panax notoginsenoside,a typical multiple constituent traditional Chinese medicine(TCM)in rats[J].Biol Pharm Bull,2007,30(5):847-851.
• [2]　LEUNG K W,YUNG K K L,MAK N K,et al.Angiomldulatory and neurological effects of ginsenosides[J].Curr Med Chem,2007,14(12):1371-1380.
• [3]　CHENG Y,SHEN L H,ZHANGJ T.Anti-amnestic and anti-aging effects of ginsenoside Rg1and Rb1and its mechanismof action[J].Acta Pharmacol Sin,2005,26(2):143-149.
• [4]　van KAMPEN J,ROBERTSON H,HAGG T,et al.Neuroprotective actions of the ginseng extract G115in two rodent models of Parkinson’s disease[J].Exp Neurol,2003,184(1):521-529.
• [5]　ZHANG G,LIU A,ZHOU Y,et al.Panax ginseng ginsenoside-Rg2protects memory impairment via anti-apoptosis in a rat model with vascular dementia[J].J Ethnopharmacol,2008,115(3):441-448.
• [6]　LIAN X Y,ZHANG Z Z,JANET L.Anticonvulsant and neuroprotective effects of ginsenosides in rats[J].Epilepsy Res,2006,70(2-3):244-256.
• [7]　LEE S H,JUNGB H,KIMS Y,et al.The antistress effect of ginseng total saponin and ginsenoside Rg3and Rb1evaluated by brain polyamine level under immobilization stress[J].Pharmacol Res,2006,54(1):46-49.
• [8]　SHENL,ZHANGJ.Ginsenoside Rg1increases ischemia-induced cell proliferation and survival inthe dentate gyrus of adult gerbils[J].Neurosci Lett,2003,344(1):1-4.
• [9]　LIAO B,NEWMARK H,ZHOUR.Neuroprotective effects of ginseng total saponin and ginsenosides Rb1and Rg1on spinal cord neurons in vitro[J].Exp Neurol,2002,173(2):224-234.
• [10]　KIMS,NAH S Y,RHIM H.Neuroprotective effects of ginseng saponins against L-type Ca2+channel-mediated cell death in rat cortical neurons[J].Biochem Biophys Res Commun,2008,365(3):399-405.
• [11]　NAVAL M V,GOMEZ-SERRANILLOS M P.Neuroprotective effect of a ginseng(Panax ginseng)root extract on astrocytes primary culture[J].J Ethnopharmacol,2007,112(2):262-270.
• [12]　ZHANG Q H,WUC F.Protective effects of total saponins from stem and leaf ofPanax ginsengagainst cyclophosphamide-induced genotoxicity and apoptosis in mouse bone marrow cells and peripheral lymphocyte cells[J].Food ChemToxicol,2008,46(1):293-302.
• [13]　LI G X,LIUZ Q.The protective effects of ginsenosides on human erythrocytes against hemin-induced hemolysis[J].Food ChemToxicol,2008,46(3):886-892.
• [14]　JIANG QS,HUANG X N.Inhibitory effect of ginsenoside Rb1on cardiac hypertrophyinduced by monocrotaline in rat[J].J Ethnopharmacol,2007,111(3):567-572.
• [15]　MINJ K,KIMJ H,CHO Y L,et al.20(S)-Ginsenoside Rg3prevents endothelial cell apoptosis via inhibition of a mitochondrial caspase pathway[J].Biochem Biophys Res Commun,2006,349(3):987-994.
• [16]　KANGS Y,SCHINI-KERTHVB,KIMND.Ginsenosides of the protopanaxatriol group cause endothelium-dependent relaxationin the rat aorta[J].Life Sci,1995,56(19):1577-1586.
• [17]　LINGC,LI Y,ZHU X,et al.Ginsenosides may reverse the dexamethasone-induced down-regulation of glucocorticoid receptor[J].Gen Comp Endocrinol,2005,140(3):203-209.
• [18]　KIM H S,LEE J H,GOO Y S,et al.Effects of ginsenosides on Ca2+channels and membrane capacitancein rat adrenal chromaffin cells[J].Brain Res Bull,1998,46(3):245-251.
• [19]　NOCERINO E,AMATO M,IZZO A A.The aphrodisiac and adaptogenic properties of ginseng[J].Fitoterapia,2000,71(1):S1-S5.
• [20]　LIU WK,XUS X,CHE C T.Anti-proliferative effect of ginseng saponins on human prostate cancer cell line[J].Life Sci,2000,67(11):1297-1306.
• [21]　HOFSETHLJ,WARGOVICHMJ.Inflammation,cancer,andtargets of ginseng[J].J Nutr,2007,137(1):183S-185S.
• [22]　LIUP,YINH,XUY,et al.Effects of ginsenoside Rg1on postimplantation rat and mouse embryos cultured in vitro[J].Toxicol In Vitro,2006,20(2):234-238.
• [23]　CHANL Y,CHIUP Y,LAUTK.Embryotoxicity study of ginsenoside Rc and Re in in vitro rat whole embryo culture[J].Reprod Toxicol,2004,19(1):131-134.
• [24]　CHANL Y,CHIU P Y,LAU T K.An in-vitro study of ginsenoside Rb1-induced teratogenicity using a whole rat embryo culture model[J].Hum Reprod,2003,18(10):2166-2168.
• [25]　POINDEXTER B J,ALLISON A W,BICK R J,et al.Ginseng:cardiotonic in adult rat cardiomyocytes,cardiotoxic in neonatal rat cardiomyocytes[J].Life Sci,2006,79(25):2337-2344.