李美艳;王永治;阿依古丽·阿里木;海且木汗·阿不杜热曼;刘早玲;

• 1:新疆医科大学公共卫生学院

摘要(Abstract)：

目的利用Meta分析方法评价多溴联苯醚(polybrominated diphenyl ethers,PBDEs)与2型糖尿病(type 2 diabetes mellitus,T2DM)的关联性。方法计算机检索万方数据库、中国知网、维普中文科技期刊数据库、中国生物医学文献服务系统等中文数据库及PubMed、OVID、Research Gate、Cochrane databases等英文数据库,收集研究PBDEs与T2DM关联性的观察性研究。经过文献筛选、资料提取和质量评价后,采用RevMan5.3软件进行Meta分析。结果共纳入7篇合格文献,包括病例和对照为1 276、5 135例。Meta分析显示,暴露于PBDEs与T2DM发病风险有关,OR(95%CI)值为1.47(1.16,1.85),P<0.05。对PBDEs的常见的同系物进行单独分析,发现BDE-47与T2DM发病风险有关,OR(95%CI)值为1.52(1.08,2.14),P<0.05。BDE-99、BDE-153、BDE-183与T2DM发病风险均无关。结论 PBDEs暴露很可能是T2DM发病的危险因素,但其病因学方面的联系,仍需要进一步高质量的研究加以证实。

关键词(KeyWords)： 多溴联苯醚;2型糖尿病;Meta分析

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(81760596);; 新疆维吾尔自治区自然科学基金(2019D01C209)

作者(Author): 李美艳;王永治;阿依古丽·阿里木;海且木汗·阿不杜热曼;刘早玲;

Email:

DOI: 10.13421/j.cnki.hjwsxzz.2020.05.012

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