紫外线辐射对人类皮肤健康的影响
李立;白雪涛;
摘要(Abstract)：
皮肤作为人体最大的器官,直接与外界环境接触,是紫外线作用的主要靶器官之一。不同波段紫外线辐射所引起的生物学效应也有所不同,UVB主要引起皮肤红斑、免疫抑制及皮肤癌,UVA则引起皮肤晒黑、皮肤光敏反应及皮肤光老化。研究认为适度晒黑有利于阻止紫外线进入皮肤深层,对皮肤有一定的保护作用。本文主要从紫外线辐射对人类皮肤健康的影响等方面进行综述,并对其可能的作用机制进行简要的阐述。
关键词(KeyWords)： 紫外线;皮肤晒伤;皮肤光敏反应;皮肤光老化;皮肤癌
基金项目(Foundation):
作者(Author): 李立;白雪涛;
Email:
DOI:
参考文献(References)：
- [1]王炳忠.太阳辐射能的测量与标准[M].北京:科学出版社,1988:4.
- [2]LCHMANN B.The vitamin D3 pathway in human skin andits role for regulation of biological processes[J].PhotochemPhotobiol,2005,81:1246-1251.
- [3]SLINEY D H.Photoprotection of the eye—UV radiationand sunglasses[J].Photochem Photobiol,2001,64:166-175.
- [4]GUZMAN E,LANGOWSKI J L,OWEN-SCHAUB L.Maddogs,Englishmen and apoptosis:the role of cell death inUV-induced skin cancer[J].Apoptosis,2003,8(4):315-325.
- [5]刘玮.日光反应性皮肤分型及其影响因素分析[J].临床皮肤科杂志,2003,32(3):174-176.
- [6]HARRISON G I,YOUNG A R.Ultraviolet radiation-induced erythema in human skin[J].Methods,2002,28:14-19.
- [7]HARRISON G I,YOUNG A R,MCMAHON S B.Ultravioletradiation-induced inflammation as a model for cutaneoushyperalgesia[J].J Invest Dermatol,2004,122:183-189.
- [8]刘玮.皮肤晒黑的光生物学基础[J].中华皮肤科杂志,2004,37(12):744-746.
- [9]VEIEROD M B.A prospective study of pigmantation,sunexposure,and risk of cutaneous malignant melanoma inwomen[J].J Natl Cancer Inst,2003,95:1530-1538.
- [10]ZANETTI R,PROTA G,NAPOLITANO A,et al.Development of an integrated method of skin phenotypemeasurement using the melanins[J].Melanoma Res,2001,11(6):551-557.
- [11]AGAR N,YOUNG A R.Melanogenesis:a photoprotectiveresponse to DNA damage[J].Mut Res,2005,571:121-132.
- [12]STEIN K R,SCHEINFELD N S.Drug-induced photoallergicand phototoxic reactions[J].Expert Opin Drug Saf,2007,6(4):431-443.
- [13]LANKERANI L,BARON E D.Photosensitivity to exogenousagents[J].J Cutan Med Surg,2004,4(6):424-431.
- [14]van de PAS C B,KELLY D A,SEED P T,et al.Ultravioletradiation induced erythema and suppression of contacthypersensitivity responses in patients with polymorphic lighteruption[J].J Invest Dermatol,2004,122:295-299.
- [15]HE Y Y,HUANG J L,GENTRY J B,et al.Epidermalgrowth factor receptor down-regulation induced by UVA inhuman keratinocytesdoes not require the receptor kinaseactivity[J].J Biol Chem,2003,278(43):42457-42465.
- [16]MAZIERE C,FLORET S,SANTUS R,et al.Impairment ofthe EGF signaling pathway by the oxidative stress generatedwith UVA[J].Free Radic Biol Med,2003,34(6):629-636.
- [17]YAAR M,GILCHREST B A.Photoageing:mechanism,prevention and therapy[J].Br J Dermatol,2007,157:874-887.
- [18]RIJKEN F,KIEKENS R C,BRUIJNZEEL P L.Skin-infiltrating neutrophils following exposure to solar-simulatedradiation could play an important role in photoageing ofhuman skin[J].Br J Dermatol,2005,152:321-328.
- [19]KOSMADAKI M G,GILCHREST B A.The role oftelomeres in skin aging/photoaging[J].Micron,2004,35:155-159.
- [20]GALLAGHER R P,LEE T K.Adverse effects of ultravioletradiation:a brief review[J].Prog Biophys Mol Biol,2006,92:119-131.
- [21]MACKIE R M.Long-term health risk to the skin ofultraviolet radiation[J].Prog Biophys Mol Biol,2006,92:92-96.
- [22]LISBY S,GNIADECKI R,WULF H C.UV-induced DNAdamage in human keratinocytes:quantitation and correlationwith long-term survival[J].Exp Dermatol,2005,14:349-355.
- [23]ULLRICH S E.Photoimmune suppression andphotocarcinogenesis[J].Front Biosci,2002,7:d684-d703.
- [24]WOODS G M,MALLEY R C,MULLER H K.The skinimmune system and the challenge of tumourimmunosurveillance[J].Eur J Dermatol,2005,15:63-69.